产品说明
应用
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. The biological functions mediated by RANK include activation of NF-
生化/生理作用
TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand, osteoprotegerin ligand and osteoclast differentiation factor) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-κB and c-jun N-terminal kinases, enhancement of T cell growth and dentritic cell function, induction of osteoclastogenesis, and lymph node genesis. Soluble RANK is able to block TRANCE-induced biological activity.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
分析说明
The biological activity is measured by its ability to inhibit TRANCE-induced osteoclast differentiation in mouse splenocytes.
基本信息
| MDL编号 | MFCD03703131 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 重组 | expressed in NSO cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 效能 | 10.12 μg/mL EC50 |
| 分子量 | 60 kDa |
| 包装 | pkg of 1 mg |
| 储存条件 | avoid repeated freeze/thaw cycles |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| UniProt登记号 | O35305 |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Tnfrsf11a(21934) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
