Damnacanthal-CAS 477-84-9-Calbiochem

产品说明

一般描述

A cell-permeable, potent, reversible, and selective inhibitor of p56^lck tyrosine kinase activity. Inhibits p56^lck autophosphorylation (IC₅₀ = 17 nM) and phosphorylation of an exogenous peptide by p56^lck over PKA and PKC and >40 fold selectivity for p56^lck over EGF, c-erbB2, insulin, and the PDGF receptor tyrosine kinases. In addition, damnacanthal exhibits 7-20 fold selectivity for p56^lck over pp60^src and pp59^fyn. Inhibition of p56^lck by damnacanthal appears to be reversible, not time-dependent and not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties, and to reverse the phenotype of ras-transformed cells.
A cell-permeable, potent, reversible, and selective inhibitor of p56^lck tyrosine kinase. Inhibits p56^lck autophosphorylation (IC₅₀ = 17 nM) and phosphorylation of an exogenous peptide by p56^lck (IC₅₀ = 620 nM). Exhibits over 100-fold greater selectivity for p56^lck over PKA and PKC, 40-fold greater selectivity for p56^lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56^lck over p60^src and p59^fyn. Inhibition of p56^lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
p56^lck autophosphorylation
Target IC₅₀: 17 nM against p56lck autophosphorylation
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Faltynek, C.R., et al. 1995. Biochemistry34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett.73, 161.
Koumaglo, K., et al. 1992. Planta Med.58, 533.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息