产品说明
生化/生理作用
The complement system is a complex cascade involving proteolytic cleavage of serum glycoproteins often activated by cell receptors. This cascade ultimately results in induction of the inflammatory response, phagocyte chemotaxis and opsonization, and cell lysis.
A complex of complements C5b, C6, C7, and C8 mediates the polymerization of up to eighteen C9 molecules into a tube-like membrane attack complex that is inserted into the plasma membrane of unwanted organisms, such as of Gram-negative bacteria and viral infected cells. This channel through the lipid bilayer results in lysis of the cell.
Human Complement C7 is a β-2-globulin, which is composed of a single polypeptide chain. The initial binding of C7 and C6 to C5b is thought to form a stable complex for subsequent binding of C8 and C9. The resulting activated complex is responsible for membrane attack and lysis.
质量
Functionally active by a sensitive hemolytic assay.
基本信息
| MDL编号 | MFCD00130845 |
| NACRES | NA.75 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human serum |
| 测定 | ≥85% (SDS-PAGE) |
| 形式 | solution |
| specific activity | ≥150,000 C7H50 units/mg protein |
| 浓度 | 1 mg/mL in 10 mM sodium phosphate, 150 mM sodium chloride, pH 7.2 |
| technique(s) | activity assay: suitable |
| UniProt登记号 | P10643 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... C7(730) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
