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Anti-phospho-PAK1/2/3 (pThr423) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P7746
规格纯度
affinity isolated antibody, buffered aqueous glycerol solution
参考价格
9341.66 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

p21-activated kinases are a family of highly conserved serine/threonine protein kinases that are activated by small GTPases of Cdc42 and Rac families. There are 2 groups of PAKs in mammals, group A and B. The group A members are three isoforms, PAK1, PAK2, and PAK3 (also known as α-PAK, γ-PAK, and β-PAK, respectively). PAKs are actively involved in regulation of MAPK pathways by phosphorylation of Raf-1 and MEK-1. They also regulate cytoskeletal reorganization by interaction with GTPases. Autophosphorylation of threonine 423 (threonine 402 for PAK2 and threonine 421 for PAK3), catalyzed by Cdc42, is required for activation of PAK.
The antibody detects human PAK1, PAK2 and PAK3, phosphorylated at Thr423. Other species with 100% PAK homology are expected to react.

免疫原

synthetic phosphopeptide derived from the region of PAK that contains threonine 423.

应用

A recommended working concentration of 0.1-1.0 μg/mL is determined by immunoblotting using Histagged wild-type and S139A/T421A double mutant PAK3.

外形

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD06411891
NACRESNA.44

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
species reactivityhuman
technique(s)western blot: 1:1,000 using His-tagged wild-type and S139A/T421A double mutant PAK3.
UniProt登记号Q13153
运输wet ice
储存温度−20℃
Gene Informationhuman ... PAK1(5058)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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