产品说明
一般描述
DARPP32 is a phosphoprotein with a molecular mass of 32kDa. It is regulated by dopamine (DA) and cAMP and is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. DARPP32 is a target for the actions of dopamine.
免疫原
synthetic phosphopeptide corresponding to amino acids residues surrounding the DARPP32 phosphorylated on threonine 34
生化/生理作用
Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32. When phosphorylated on threonine 34, DARPP32 acts as a potent protein phosphatase- inhibitor. This phosphorylation plays an important role in the regulation of dopaminergic neurotransmission. The activity of this protein has an important role in the actions of alcohol, caffeine and Prozac®.
目标描述
DARPP32 phosphorylated on Thr75 acts as an inhibitor of PKA.
外形
Solution at 100 μL in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.
法律信息
Prozac is a registered trademark of Eli Lilly and Co.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD08705495 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous glycerol solution |
| 用途 | sufficient for 10 blots |
| 分子量 | ~32 kDa |
| species reactivity | rat, mouse |
| technique(s) | western blot: 1:1,000 using rat caudate lysates |
| UniProt登记号 | Q6J4I0 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PPP1R1B(84152) mouse ... Ppp1r1b(19049) rat ... Ppp1r1b(360616) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
