Anti-phospho-c-Jun (pSer⁷³) antibody produced in rabbit

产品说明

特异性

The antibody does not react with non-phosphorylated c-Jun or JunD. It does react with the JunD phosphorylated at Ser¹⁰⁰, a site conserved between c-Jun and JunD.

免疫原

synthetic phosphoserine⁷³ peptide corresponding to residues around Ser⁷³ of human c-Jun, conjugated to KLH.

应用

Anti-phospho-c-Jun (pSer73) antibody produced in rabbit has been used in microarray analysis to identify the changes in the level of cellular proteins in cells inoculated with Equine influenza virus.

生化/生理作用

The protooncogene c-Jun encodes a member of the Jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes.

外形

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol

制备说明

Purified using protein A and peptide affinity chromatography.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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