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Anti-DFF45, N-Terminal antibody produced in rabbit

品牌
Sigma-Aldrich
货号
D3438
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
4330.86 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

DFF exists as an inactive cytoplasmic protein until activated by apoptotic signals. DFF40, the nuclease responsible for DNA fragmentation during apoptosis, exists as a heterodimeric complex with DFF45.

免疫原

synthetic peptide corresponding to amino acids 2-21 of the N-terminal region of human DFF45/ICAD (DNA Fragmentation Factor 45/Inhibitor of Caspase-3 Activated DNase I).

应用

Anti-DFF45 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 0.5μg/mL using a total HeLa cell lysate.

生化/生理作用

DFF45 functions as both a chaperone, mediating the correct folding of DFF40, and an inhibitor of DFF40. DFF45 is cleaved by caspase-3 at two sites in response to apoptotic signals. This releases DFF40, the active nuclease. DFF40 seems to oligomerize, forming a large, functional complex which breaks down DNA by introducing double strand breaks. Also, DFF40 appears to interact directly with histone H1 that may stimulate its activity.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

基本信息

MDL编号MFCD02096210
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 45 kDa (non-apoptotic cells)
species reactivityhuman
technique(s)western blot: 0.5 μg/mL using human HeLa cell extract
UniProt登记号O00273
运输dry ice
储存温度−20℃
Gene Informationhuman ... DFFA(1676)

Sigma-Aldrich

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