产品说明
应用
GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.
生化/生理作用
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
数量
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
基本信息
| 经验(实验)分子式 | C25H24N4O2 |
| 分子量 | 412.48 |
| MDL编号 | MFCD00236428 |
| PubChem化学物质编号 | 329799908 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 生物来源 | synthetic |
| 测定 | ≥90% (HPLC) |
| 溶解性 | DMSO: soluble (~1 mg/ml) |
| 储存温度 | 2-8℃ |
| SMILES string | CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 |
| InChI | 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChI key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H351 |
| 预防措施声明 | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| 危险分类 | Carc. 2 |
| 补充剂危害 | EUH019 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
