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Anti-Bax antibody produced in rabbit

品牌
Sigma-Aldrich
货号
B3428
规格纯度
IgG fraction of antiserum, buffered aqueous solution
参考价格
5184.65 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Bax is a 21kD integral organelle membrane protein that belongs to the Bcl-2 family and is expressed mainly in the mitochondria. It exist in three cytosolic forms Bax β (24 kDa), Bax γ (5 kDa) and Bax δ (16 kDa) generated by alternative splicing.

免疫原

synthetic peptide GGPTSSEQIMKTGALLLQGF-K corres- ponding to the N-terminal region of Bax of human origin (Bax α, amino acids 11-30 with C-terminally added lysine), conjugated to KLH as immunogen. This sequence is identical in human Bax β and highly conserved in rat and mouse Bax α (single amino acid substitution) and human Bax.

应用

Anti-BMPR2 (836-850) antibody produced in rabbit is suitable for western blotting at a concentration of 1:500-1:2,000.

生化/生理作用

BAX is a proapoptotic protein that forms homodimer to accelerate apoptotic death whereas its heterodimerization with Bcl-2 or Bcl-xL can block apoptosis. BAX binds to the mitochondrial permeability transition pore complex (PTPC), and when expressed in cells, it induces mitochondrial dysfunction and the release of cytochrome C, leading to activation of caspases and triggers apoptosis. Loss-of-function mutation in the BAX gene results in Hematopoietic malignancies.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00282585
NACRESNA.46

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 23 kDa
species reactivityhuman, mouse, rat
technique(s)microarray: suitable
western blot: 1:2,000 using whole cell extract of MCF7 human breast adenocarcinoma cell line
UniProt登记号Q07812
运输dry ice
储存温度−20℃
Gene Informationhuman ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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