位置:首页 > 品牌 > Sigma-Aldrich >

Gold nanoparticles

品牌
Sigma-Aldrich
货号
765392
规格纯度
40 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O
参考价格
4335.1 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, is shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which has Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

应用

Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:

  • Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.
  • They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.

包装

1 mL in poly bottle

特点和优势

  • A negatively charged siRNA-PEG complex attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
  • The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

产品性质

质量水平100
物料PEG 5000
形式dispersion in H2O
nanoparticles
包装poly bottle of 1 mL
OD 50
直径40 nm
pH值(酸碱度)6.0-8.0 (25 ℃)
溶解性water: miscible
密度1.00 g/cm3
官能团amine
储存温度2-8℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号