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TIRAP Inhibitor Peptide, Cell-Permeable-Calbiochem

品牌
Sigma-Aldrich
货号
613570
规格纯度
The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
参考价格
4783.56 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.
A cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells
Cell permeable: yes
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Toshchakov, V., et al. 2002. Nat. Immunol.3, 392.
Fitzgerald, K.A., et al. 2001. Nature413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol.2, 828.
Horng, T., et al. 2001. Nat. Immunol.2, 835.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C163H268N52O38S
分子量3596.26

产品性质

质量水平100
测定≥97% (HPLC)
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 white
溶解性DMSO: 5 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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