产品说明
一般描述
A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC50 = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.
A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC50 = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17)
Primary Target
TNF-α converting enzyme/ADAM17
Product does not compete with ATP.
Reversible: no
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.
法律信息
Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C24H32N4O5 |
| 分子量 | 456.53 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥96% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 颜色 | white |
| 溶解性 | 50% acetic acid: 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | −20℃ |
| InChI | 1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1 |
| InChI key | CRCPLBFLOSEABN-VBSNWNEZSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
