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InSolution IKK-2 Inhibitor, SC-514-Calbiochem

品牌
Sigma-Aldrich
货号
401485
规格纯度
The InSolution IKK-2 Inhibitor, SC-514 controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
参考价格
1903.37 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC50: ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Primary Target
IKK-2
Product competes with ATP.
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.

重悬

Following initial use, aliquot and refrigerate (4°C).

其他说明

Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett.14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem.278, 32861.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C9H8N2OS2
分子量224.30

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色clearpale yellow
运输wet ice
储存温度2-8℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

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