产品说明
一般描述
A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase (IC50 = 13 µM for Aβ). Displays only weak inhibitory activity against calpain II (IC50 = 100 µM in a purified enzyme assay).
Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable, reversible and selective peptidomimetic inhibitor of γ-secretase with an IC50 of 13 µM for the inhibition of amyloid β-protein (Aβ) production in β-amyloid precursor protein (APP)-transfected Chinese hamster ovary cells. Displays only weak inhibitory activity against calpain II (IC50 = 100 µM in a purified enzyme assay).
包装
1 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Primary Target
γ-secretase
Product does not compete with ATP.
Target IC50: 13 µM against γ-secretase
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Wolfe, M.S., et al. 1999. Biochemistry38, 4720.
Wolfe, M.S., et al. 1998. J. Med. Chem. 41, 6.
Citron, M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 13170.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C33H57F2N5O9 |
分子量 | 705.83 |
产品性质
质量水平 | 100 |
测定 | ≥95% (HPLC) |
形式 | solid |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze |
颜色 | white |
溶解性 | DMSO: 10 mM |
运输 | ambient |
储存温度 | −20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |