位置:首页 > 品牌 > Sigma-Aldrich >

Caspase Inhibitor Set III-Calbiochem

品牌
Sigma-Aldrich
货号
218806
规格纯度
The Caspase Inhibitor Set III controls the biological activity of Caspase. This collection of small molecule/inhibitor is primarily used for Cancer applications.
参考价格
12848.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Apoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.



Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
A set of eight ready to use cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 25 µl (2 mM) each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 627610). Supplied with a data sheet.

包装

1 set in Glass bottle

生化/生理作用

Cell permeable: yes
Reversible: no
Primary Target
Caspase-1, caspase-2, caspase-3, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8

警告

Toxicity: Irritant (B)

外形

Supplied as 2 mM in DMSO.

其他说明

Humke, E.W., et al. 1998. J. Biol. Chem.273, 15702.
Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
Takahashi, A., et al. 1997. Exp. Cell Res.231, 123.
Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
Nicholson, D.W., et al. 1995. Nature376, 37.
Thornberry, N.A., et al. 1992. Nature356, 768.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

产品性质

质量水平100
形式liquid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
运输wet ice
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号