产品说明
一般描述
A potent non-steroidal anti-inflammatory drug that inhibits both COX-1 (IC50 = 76 nM) and COX-2 (IC50 = 26 nM) activities. Also inhibits liver phenol sulfotransferase activity (IC50 ~9.5 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation.
A cell-permeable, non-selective cyclooxygenase inhibitor (IC50 = 60 nM and 200 nM for ovine COX-1 and COX-2 respectively) and potent non-steroidal anti-inflammatory drug with analgesic activity. Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Also inhibits liver phenol sulfotransferase activity (IC50 = 9.5 µM).
生化/生理作用
Cell permeable: yes
Target IC50: 60 nM and 200 nM for ovine COX-1 and COX-2 respectively; 9.5 µM against liver phenol sulfotransferase activity
Primary Target
COX-1
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
重悬
Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
其他说明
Kato, M., et al. 2001. J. Pharm. Pharmacol.53, 1679.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Vietri, M., et al. 2000. Eur J. Clin. Pharmacol. 56, 81.
Merlos, M., et al. 1996. Inflamm. Res.45, 20.
Goa, K.L., and Chrisp, P. 1992. Drugs Aging 2, 473.
Kurowski, M., and Dunky, A. 1992. Int. J. Clin. Pharmacol. Ther. Toxicol. 30, 479.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C14H10Cl2NO2 · Na |
| 分子量 | 318.13 |
| MDL编号 | MFCD00082251 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | water: 25 mg/mL |
| 运输 | ambient |
| 储存温度 | 10-30℃ |
| InChI | 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1 |
| InChI key | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
安全信息
| 象形图 |    |
| 警示用语： | Danger |
| 危险声明 | H301 - H361d - H372 - H411 |
| 预防措施声明 | P201 - P202 - P260 - P264 - P273 - P301 + P310 |
| 危险分类 | Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1 |
| 储存分类代码 | 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
