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Monoclonal Anti-UCHL1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0007345M1
规格纯度
clone 1B8-4D2, purified immunoglobulin, buffered aqueous solution
参考价格
6644.93 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease
Ubiquitin C-terminal hydrolase L1 (UCHL1) is encoded by the gene mapped to human chromosome 4p14. The encoded protein is a deubiquitinase, which is part of the ubiquitin proteasome system (UPS). UCHL1 is specifically expressed in the nervous system and gonads.

免疫原

UCHL1 (AAH00332, 1 a.a. ~ 223 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA

生化/生理作用

Ubiquitin C-terminal hydrolase L1 (UCHL1) catalyzes the hydrolysis of carboxy-terminal ubiquitin esters and amides. It plays an essential role in epithelial-mesenchymal transition. In addition, UCHL1 is also implicated in the cell invasion and in the cell cycle regulation. UCHL1 gene acts as an oncogene in various types of cancers including glioma, gastric cardiac adenocarcinoma (GCA) and colorectal cancer. It also acts as a susceptibility gene for Parkinson′s disease.

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆1B8-4D2, monoclonal
形式buffered aqueous solution
species reactivityrat, mouse, human
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型IgG1κ
GenBank® accession no.BC000332
UniProt登记号P09936
运输dry ice
储存温度−20℃
Gene Informationhuman ... UCHL1(7345)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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