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Monoclonal Anti-CDK5 antibody produced in mouse

品牌
Sigma-Aldrich
货号
WH0001020M1
规格纯度
clone 1A2, ascites fluid
参考价格
4474.51 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Cyclin-dependent kinase 5 (Cdk5) is encoded by the gene mapped to human chromosome 7q36. The encoded protein is a proline-directed serine threonine kinase and is a member of cyclin-dependent kinase (Cdk) family. Cdk5 is highly expressed in the nervous system.

免疫原

CDK5 (AAH05115, 195 a.a. ~ 292 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP

生化/生理作用

Cyclin-dependent kinase 5 (Cdk5) plays a vital role in normal development of the mammalian central nervous system. It is also implicated in regulation of migration and neuronal plasticity. Cdk5, expressed in neurons, modulates cytoskeletal elements, axonal guidance, membrane transport, synaptogenesis and cell survival during both normal and pathological conditions. Downregulated expression of the gene is associated with various types of disease such as Alzheimer′s disease, amyotrophic lateral sclerosis, Parkinson′s disease, Huntington′s disease and acute neuronal injury.

外形

Solution

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00282840
NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式ascites fluid
antibody product typeprimary antibodies
克隆1A2, monoclonal
species reactivityhuman
technique(s)indirect ELISA: suitable
western blot: 1:500-1:1000
同位素/亚型IgMκ
GenBank® accession no.BC005115
UniProt登记号Q00535
运输dry ice
储存温度−20℃
Gene Informationhuman ... CDK5(1020)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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