产品说明
一般描述
Cyclin-dependent kinase 5 (Cdk5) is encoded by the gene mapped to human chromosome 7q36. The encoded protein is a proline-directed serine threonine kinase and is a member of cyclin-dependent kinase (Cdk) family. Cdk5 is highly expressed in the nervous system.
免疫原
CDK5 (AAH05115, 195 a.a. ~ 292 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
生化/生理作用
Cyclin-dependent kinase 5 (Cdk5) plays a vital role in normal development of the mammalian central nervous system. It is also implicated in regulation of migration and neuronal plasticity. Cdk5, expressed in neurons, modulates cytoskeletal elements, axonal guidance, membrane transport, synaptogenesis and cell survival during both normal and pathological conditions. Downregulated expression of the gene is associated with various types of disease such as Alzheimer′s disease, amyotrophic lateral sclerosis, Parkinson′s disease, Huntington′s disease and acute neuronal injury.
外形
Solution
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00282840 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | ascites fluid |
| antibody product type | primary antibodies |
| 克隆 | 1A2, monoclonal |
| species reactivity | human |
| technique(s) | indirect ELISA: suitable western blot: 1:500-1:1000 |
| 同位素/亚型 | IgMκ |
| GenBank® accession no. | BC005115 |
| UniProt登记号 | Q00535 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CDK5(1020) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
