产品说明
一般描述
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown. (provided by RefSeq)
免疫原
MAX (AAH03525, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS
生化/生理作用
Myc-associated factor X (MAX) interacts with N-, L-, and c-Myc proteins both in vitro and in vivo. MAX plays a vital role in the regulation of the MYC/MAX/ MAX dimerization protein (MXD) network of basic helix-loop-helix leucine zipper (bHLHZip) transcription factors implicated in cell proliferation, differentiation, and apoptosis. Mutation of the gene leads to pheochromocytomas and paragangliomas (PPGLs). Heterodimer complex of c-Myc and Max proteins stimulates the transcription at target promoters by binding hexameric DNA consensus sequences “CANNTG” (E-boxes). Apart from this, Max hinders MYC-dependent cell transformation by transcriptional repression of the same E-boxes by associating with various repressors such as MXD, MAX network transcriptional repressor (MNT), and MAX gene-associated protein (MGA). Gene transcription activated by MYC–MAX heterodimers can be repressed by Max homodimers by decreasing the level of free MAX monomers and by binding to E-box DNA sequences.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD01633623 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 4E10-1A9, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable indirect ELISA: suitable proximity ligation assay: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG2aκ |
| GenBank® accession no. | BC003525 |
| UniProt登记号 | P61244 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MAX(4149) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
