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Oct-2 (MRQ-2) Mouse Monoclonal Antibody

品牌
Sigma-Aldrich
货号
308M-1
包装型号
规格纯度
参考价格
2349.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing, although it seems that the level of its expression can be used as a marker of B-cell lineage and differentiation. The following show high levels of Oct-2 expression: germinal center B-cells, mantle B-cells, monocytoid B-cells, and plasma cells. Various lymphomas are also positive for this marker including the following: B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, classic Hodgkin lymphoma.
Several studies of Oct-2 expression have shown a low level expression in pre-B, T-cell, myelomonocytic, and epithelial cell lines, whereas all mature B-cell lines display high levels of expression. Analysis of Oct-2 expression in primary Hodgkin′s lymphoma (HLs) and cell lines derived from it showed that the tumor cells analyzed had high levels of expression and activity, suggesting a common B-cell origin for all types of HLs.
Associated products: bcl-6, CD20, CD79a, PAX-5, BOB.1

质量


IVD

IVD

IVD

RUO

联系

Oct-2 Positive Control Slides, Product No. 308S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.41

产品性质

质量水平500
100
生物来源mouse
偶联物unconjugated
抗体形式diluted ascites fluid
antibody product typeprimary antibodies
克隆MRQ-2, monoclonal
描述For In Vitro Diagnostic Use in Select Regions (See Chart)
形式buffered aqueous solution
species reactivityhuman
包装vial of 0.1 mL concentrate (308M-14)
vial of 0.5 mL concentrate (308M-15)
bottle of 1.0 mL predilute (308M-17)
vial of 1.0 mL concentrate (308M-16)
bottle of 7.0 mL predilute (308M-18)
manufacturer/tradenameCell Marque
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型IgG1κ
控制tonsil
运输wet ice
储存温度2-8℃
可视化nuclear

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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