产品说明
一般描述
Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene. It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas). MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL). Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma. However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive. MUM1 is also expressed in plasma cell myeloma.
质量
 IVD |  IVD |  IVD |  RUO |
联系
MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
产品性质
| 质量水平 | 500 100 |
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | culture supernatant |
| antibody product type | primary antibodies |
| 克隆 | EP190, monoclonal |
| 描述 | For In Vitro Diagnostic Use in Select Regions |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | vial of 0.1 mL concentrate (358R-14) vial of 0.1 mL concentrate Research Use Only (358R-14-RUO) vial of 0.5 mL concentrate (358R-15) vial of 1.0 mL concentrate (358R-16) vial of 1.0 mL concentrate Research Use Only (358R-16-RUO) vial of 1.0 mL pre-dilute Research Use Only (358R-17-RUO) vial of 1.0 mL pre-dilute ready-to-use (358R-17) vial of 7.0 mL pre-dilute ready-to-use (358R-18) vial of 7.0 mL pre-dilute ready-to-use Research Use Only (358R-18-RUO) |
| manufacturer/tradename | Cell Marque™ |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated) |
| 同位素/亚型 | IgG |
| 控制 | diffuse large B-cell (lymphoma), plasma cell myeloma (tumor), tonsil |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| 可视化 | cytoplasmic, nuclear |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
