基本信息
| 分子式 | C20H26N2O2S2 |
| 分子量 | 390.56 |
| 存储条件 | Freezer -20℃ |
产品描述
PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM. IC50 value: 1-10 μM (EC50) Target: HDAC in vitro: In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.
靶点（IC50 & Targe）
HDAC
参考文献
[1]. Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-1032.
安全信息
| 图形或危害标志 |  |
| 提示语 | Danger |
| 危险说明 | H318 H413 |
| 防范说明 | P273 P280 P305+P351+P338 P310 P501 |
