基本信息
| 分子式 | C41H78NO8P |
| 分子量 | 744.03 |
| 熔点 | 200 |
| MDL编码 | MFCD00057986 |
| Beilstein | 1718431 |
| 存储条件 | Freezer -20℃ |
产品描述
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid)，与阳离子磷脂结合，提高裸 siRNA 的转染效率。
靶点（IC50 & Targe）
IC50: helper lipid for liposome[1]
体外研究
In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].
With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].
LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].
LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].
安全信息
| WGK | 3 |
