基本信息
| 分子式 | C28H44O2 |
| 分子量 | 412.65 |
| 熔点 | 140 |
| MDL编码 | MFCD01076571 |
| 存储条件 | Freezer -20℃ |
生化/生理作用
Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4.Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR.
安全信息
| 图形或危害标志 |  |
| 提示语 | Danger |
| 危险说明 | H300 |
| 防范说明 | P501 P270 P264 P301+P310+P330 P405 |
| UN号码 | 2811 |
| 危险分类 | 6.1 |
| 包装等级 | I |
| RTECS | VS2950000 |
