基本信息
| 分子式 | C16H30O |
| 分子量 | 238.41 |
| 熔点 | -15 |
| 沸点 | 95 |
| 密度 | 0.92 |
| 折光率(n20D) | 1.4770-1.4810 |
| MDL编码 | MFCD00211114 |
| Beilstein | 2047145 |
| Merck | (14)6313 |
| 存储条件 | Store at 2-8℃ |
产品描述
Muscone, a flavouring ingredient, is an organic compound that is the primary contributor to the odor of musk and also a potent anti-inflammatory agent
靶点（IC50 & Targe）
MMP-9
P-gp (P-glycoprotein),
体外研究
Muscone induces CYP1A2 and CYP3A4 expression in liver cells in vitro and in vivo[1]. Muscone protects PC12 cells against glutamate-induced apoptosis by attenuating ROS generation and Ca2+ influx, via NR1 and CaMKII-depended ASK-1/JNK/p38 signaling pathways[2]. Muscone could promote bone marrow-derived mesenchymal stem cells (BMSCs) migration and proliferation[3].
体内研究
Muscone exhibits liver toxicity in Kunming mice at concentrations higher than 50 mg/kg[1]. It exerts potent neuroprotective activities on cerebral ischemia[2]. Muscone could accelerate the migration of BMSCs to the injured area in vivo[3].
细胞实验
Cell lines: PC12 cells
Concentrations: 0.1, 1, 10 μM
Incubation Time: 1 h
Method: PC12 cells are seeded in 96-well culture plates at an approximate density of 1×105 cells per well and maintained in a CO2 incubator at 37 ℃ overnight. At the end of indicated treatment, MTT is added to the medium and incubated for another 4 h at 37℃. After the removal of the culture medium, the insoluble dark blue formazan crystal is dissolved with 150 μL DMSO. The absorbance (A) is measured at 490 nm with a microplate reader. Cell viability is expressed as a percentage with the control group as 100%.
(Only for Reference)
参考文献
[1] Liu S, et al. Pharmacology. 2017, 99(5-6):205-215.
[2] Yu L, et al. Neurochem Int. 2014, 70:10-21.
[3] Pengfei Liu, et al. PLoS One. 2014, 9(5): e97123.
安全信息
| 图形或危害标志 |  |
| 提示语 | Warning |
| 危险说明 | H315 H319 |
| 防范说明 | P264 P280 P302+P352+P332+P313+P362+P364 P305+P351+P338+P337+P313 |
| RTECS | GY0950000 |
