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BML-210

品牌
J&K
CAS
537034-17-6
货号
299852
规格纯度
96%, 一类新颖的HDAC抑制剂
参考价格
912 *本价格含增值税费
促销
数量
-+
产品介绍:

基本信息

分子式C20H25N3O2
分子量339.43
MDL编码MFCD08062139
存储条件Freezer -20℃

产品描述

BML-210 is a novel HDAC inhibitor, and its mechanism of action has not been characterized. IC50 value: 5 μM[1] Target: HDAC4 In vitro: Cell cycle analysis indicated that HeLa cell treatment with 20 and 30 μM concentration of BML-210 increased the proportion of cells in G0/G1 phase, and caused accumulation in subG1, indicating that the cells are undergoing apoptosis[2]. BML-210 inhibits the growth of NB4 cells in dose- and time-dependent manner[3].

靶点(IC50 & Targe)

HDAC

参考文献

[1]. Nimanthi Jayathilaka, et al. Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2. Nucleic Acids Res. 2012 Jul; 40(12): 5378–5388.

[2]. Veronika V. Borutinskaite, et al. Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Mol Biol Rep (2012) 39:10179–10186

[3]. Veronika Borutinskaite, et al. The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Int J Mol Sci. 2015 Aug; 16(8): 18252–18269.

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