基本信息
| 分子式 | C20H28N6O3 |
| 分子量 | 400.47 |
| 存储条件 | Freezer -20℃ |
产品描述
CVT-313是有效的CDK2抑制剂，在体外的IC50值为0.5 μM。它对其他非相关的、依赖于ATP的丝氨酸/苏氨酸激酶没有作用。
靶点（IC50 & Targe）
CDK1,4.2μM
CDK2,0.5μM
CDK4,215μM
体外研究
In cells exposed to CVT-313, hyperphosphorylation of the retinoblastoma gene product is inhibited, and progression through the cell cycle is arrested at the G1/S boundary. The growth of mouse, rat, and human cells in culture is also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 μM. CVT-313 inhibits Rb hyperphosphorylation[1].
细胞实验
Cell lines: MRC-5 cells
Concentrations: 12.5 μM
Incubation Time: 24 h
Method: --
(Only for Reference)
动物实验
Animal Models: Rat carotid artery model of restenosis
Formulation: saline
Dosages: 0.025, 0.25, 0.75, 1.25 mg/kg
Administration: intraluminal
(Only for Reference)
参考文献
[1] Brooks EE, et al. J Biol Chem. 1997, 272(46):29207-11.
安全信息
| 图形或危害标志 |   |
| 提示语 | Danger |
| 危险说明 | H315 H317 H318 H334 H335 H341 H361 H370 H413 |
| 防范说明 | P201 P202 P260 P264 P270 P271 P272 P273 P280 P302+P352 P304+P340 P305+P351+P338 P310 P321 P362 P405 |
