产品介绍：
基本信息
| 分子式 | C22H23N5O2S |
| 分子量 | 421.52 |
| 存储条件 | Freezer -20℃ |
产品描述
SW-044248是非经典的Topo1抑制剂，对非小细胞肺癌细胞具有选择性毒性作用。
靶点（IC50 & Targe）
Topo I
体外研究
SW044248 is selectively toxic for some NSCLC cell lines. SW044248 rapidly inhibits transcription, translation and DNA synthesis in sensitive cells but not insensitive cells. The acute transcriptional response to SW044248 correlates with the response to agents that cause DNA damage[1].
细胞实验
Cell lines: NSCLC cell lines
Concentrations: --
Incubation Time: 96 h
Method:Cell viability assay
(Only for Reference)
参考文献
[1] Iryna O. Zubovych, et al. Mol Cancer Ther. 2016, 15(1): 23-36.
