应用
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

备注
Moisture, Heat, water Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents. Stable under recommended storage conditions.

基本信息

MDL
MFCD00000888

EINECS
223-589-8

分子式
C₄H₉ClO₂

分子量
124.57

沸点
50-52°/13mm

闪点
54°(129°F)

密度
1.094

折射率
1.4270

灵敏度
Moisture Sensitive. Store under Nitrogen. Store at -20°C.

形态
Liquid

溶解性
It hydrolyzes with water.

Beilstein
1900576

GHS危害和防范说明

GHS符号

Hazard Statements
H226-H315-H319-H350-H335
Flammable liquid and vapour.Causes skin irritation.Causes serious eye irritation.May cause cancer.May cause respiratory irritation.

Precautionary Statements
P210-P201-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Obtain special instructions before use.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
3

包装组
III

危险类别
45-10-36/37/38
May cause cancer.Flammable.Irritating to eyes, respiratory system and skin.

安全等级
53-45
Avoid exposure - obtain special instructions before use.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

TSCA
是