应用
Hydroxyurea is used as an inhibitor of DNA synthesis and an anti-cancer drug. It is used as a precursor to prepare 1-hydroxy-5,6-dimethyl-1H-pyrimidine-2,4-dione via reaction with 2-methyl-3-oxo-butyric acid ethyl ester. It is used in the treatment of melanoma, resistant chronic myelocytic leukemia and recurrent metastatic or inoperable ovarian. It is also involved in reducing the rate of painful attacks in sickle-cell disease and has anti-retroviral properties in diseases such as AIDS.

备注
Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.

基本信息

MDL
MFCD00007943

EINECS
204-821-7

分子式
CH₄N₂O₂

分子量
76.06

熔点
ca 140° dec.

灵敏度
Ambient temperatures.

形态
Crystalline powder

溶解性
Soluble in water, hot alcohol and dimethyl sulfoxide. Insoluble in ethanol and benzene.

Beilstein
1741548

Merck
14,4848

GHS危害和防范说明

GHS符号

Hazard Statements
H340-H360
May cause genetic defects.May damage fertility or the unborn child.

Precautionary Statements
P201-P280-P202-P308+P313-P405-P501a
Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Do not handle until all safety precautions have been read and understood.IF exposed or concerned: Get medical advice/attention.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
46-61
May cause heritable genetic damage.May cause harm to the unborn child.

安全等级
53-20-36-45
Avoid exposure - obtain special instructions before use.When using do not eat or drink.Wear suitable protective clothing.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

RTECS
YT4900000

TSCA
否