应用
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.
备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
基本信息
MDL
MFCD00511302
EINECS
207-735-8
分子式
C8H6N2O
分子量
146.15
熔点
216-219°
灵敏度
Ambient temperatures.
形态
Powder
溶解性
Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Beilstein
118473
GHS危害和防范说明
GHS符号
Hazard Statements
H302-H315-H319-H335
Harmful if swallowed.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements
P280h-P305+P351+P338
Wear protective gloves/clothing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
安全信息
危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.
安全等级
26-36/37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.
欧盟危险品标志
RTECS
VA2300000
TSCA
否
