应用
5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.
备注
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.
基本信息
MDL
MFCD00006018
EINECS
200-085-6
分子式
C4H3FN2O2
分子量
130.08
熔点
ca 282° dec.
灵敏度
Light Sensitive. Ambient temperatures.
形态
Crystalline powder
溶解性
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.
Beilstein
127172
Merck
14,4181
GHS危害和防范说明
GHS符号
Hazard Statements
H302-H341-H360-H373
Harmful if swallowed.Suspected of causing genetic defects.May damage fertility or the unborn child.May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements
P260-P201-P280-P301+P312a-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray.Obtain special instructions before use.Wear protective gloves/protective clothing/eye protection/face protection.Wear protective gloves/protective clothing/eye protection/face protection.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险等级
6.1
包装组
III
危险类别
61-22-48/22-68
May cause harm to the unborn child.Harmful if swallowed.Harmful: danger of serious damage to health by prolonged exposure if swallowed.Possible risk of irreversible effects.
安全等级
53-45
Avoid exposure - obtain special instructions before use.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
RTECS
YR0350000
TSCA
是
