应用
It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.
备注
Store at room temperature. Incompatible with strong oxidizing agents.
基本信息
MDL
MFCD00006003
EINECS
214-416-7
分子式
C8H15NO2
分子量
157.21
沸点
203-205°
闪点
80°(176°F)
密度
1.021
折射率
1.4600
灵敏度
Ambient temperatures.
形态
Liquid
溶解性
Fully miscible with water.
Beilstein
118419
GHS危害和防范说明
GHS符号
Hazard Statements
H227-H315-H319-H335
Combustible liquid.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements
P210e-P261-P280a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险类别
36/37/38
Irritating to eyes, respiratory system and skin.
安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
TSCA
否
