应用
18-Crown-6 is used as an efficient phase transfer catalyst and as a complexing agent with a variety of small cation. It is involved in the synthesis of diaryl ethers, diaryl thioethers, and diarylamines mediated by potassium fluoride-alumina and 18-crown-6. It facilitates the solubility of potassium permanganate in benzene, which is used for oxidizing the organic compounds. It is used to accelerate various substitution reactions as well as enhances the power of nucleophiles such as potassium acetate. It is utilized in the alkylation reactions in the presence of potassium carbonate, N-alkylation of glutarimide and succinimide with dimethylcarbonate. The complex formed by its reaction with potassium cyanide acts as a catalyst in the cyanosilylation of aldehydes, ketones and quinines with trimethylsilyl cyanide (TMSCN).
备注
Hygroscopic. Incompatible with strong oxidizing agents and strong acids.
基本信息
MDL
MFCD00005113
EINECS
241-473-5
分子式
C12H24O6
分子量
264.32
熔点
37-41°
沸点
116°/0.2mm
闪点
109°(228°F)
密度
1.175
灵敏度
Hygroscopic. Ambient temperatures.
形态
Crystalline lumps
溶解性
Soluble in water.
Beilstein
1619616
Merck
14,2602
GHS危害和防范说明
GHS符号
Hazard Statements
H302-H313-H319
Harmful if swallowed.May be harmful in contact with skin.Causes serious eye irritation.
Precautionary Statements
P280i-P264-P305+P351+P338-P301+P312a-P337+P313-P501a
Wear eye/face protection.Wash thoroughly after handling.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.If eye irritation persists: Get medical advice/attention.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险类别
22-36
Harmful if swallowed.Irritating to eyes.
安全等级
26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing.
欧盟危险品标志
RTECS
MP4500000
TSCA
是
