应用
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.
备注
Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.
基本信息
MDL
MFCD00006083
EINECS
256-500-6
分子式
C5H5ClN2S
分子量
160.63
熔点
ca -2°
沸点
118-120°/9mm
闪点
>110°(230°F)
密度
1.380
折射率
1.6 00
灵敏度
Store at -20°C. Moisture Sensitive. May form a Precipitate.
形态
Liquid
溶解性
Not miscible or difficult to mix in water.
Beilstein
118042
GHS危害和防范说明
GHS符号
Hazard Statements
H314-H318
Causes severe skin burns and eye damage.Causes serious eye damage.
Precautionary Statements
P260h-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险等级
8
包装组
II
危险类别
34
Causes burns.
安全等级
26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
欧盟危险品标志
TSCA
否
