应用
3-Butyn-2-one was used in the synthesis of clerodane diterpenoid (+/-)-sacacarin. It was used as substrate in stereoselective, conjugate arylation mediated by gallium(III) chloride leading to (E)-α,β-unsaturated ketones. 3-Butyn-2-one undergoes asymmetric double-Michael reaction with ortho-tosylamidophenyl malonate catalyzed by chiral aminophosphines to yield indolines2. It undergoes double Michael reaction with nitrogen-containing tethered diacid to give pipecolic acid derivatives. 3-Butyn-2-one, is used as a reactant with Dimethyl?- acetone-1,3-dicarboxyl?-ate, under mild conditions to give a benzenoid product via a Michael addition - aldol cyclization process.
备注
Stable under normal temperatures and pressures. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
基本信息
MDL
MFCD00008775
EINECS
215-834-2
分子式
C4H4O
分子量
68.08
沸点
84-86°
闪点
-1°(30°F)
密度
0.870
折射率
1.4060
灵敏度
Keep Cold.
形态
Liquid
溶解性
It is soluble in water.
Beilstein
605353
GHS危害和防范说明
GHS符号
Hazard Statements
H225-H300-H315-H318-H335
Highly flammable liquid and vapour.Fatal if swallowed.Causes skin irritation.Causes serious eye damage.May cause respiratory irritation.
Precautionary Statements
P210-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Keep away from heat/sparks/open flames/hot surfaces. - No smoking.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险等级
3
包装组
II
危险类别
11-28-37/38-41
Highly flammable.Very toxic if swallowed.Irritating to respiratory system and skin.Risk of serious damage to eyes.
安全等级
9-16-20-23-26-28-36/37/39-45
Keep container in a well-ventilated place.Keep away from sources of ignition - No smoking.When using do not eat or drink.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
欧盟危险品标志
TSCA
否
