应用
In peptide synthesis, can be used to protect the hydroxyl group of serine and threonine as the cyclohexyl (Chx) ether, by reaction with the sodium alkoxide (generated with NaH), followed by hydrogenation. The group is stable to TFA and 20% piperidine in DMF, but can be cleaved with TfOH in TFA, in the presence of thioanisole as a cation scavenger. It is also used in the synthesis of N-tert-butoxycarbonyl-O-cyclohexyl-L-tyrosine.1 It was also used in the synthesis of enantiopure cyclohexitols such as muco-quercitol, D-chiro-inocitol and allo-inocitol.
备注
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
基本信息
MDL
MFCD00013775
分子式
C6H9Br
分子量
161.05
沸点
64-65°/15mm
闪点
54°(129°F)
密度
1.400
折射率
1.5310
灵敏度
Keep Cold.
形态
Liquid
溶解性
Not miscible or difficult to mix in water.
Beilstein
635953
GHS危害和防范说明
GHS符号
Hazard Statements
H226-H315-H319-H335
Flammable liquid and vapour.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.
Precautionary Statements
P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Avoid breathing dust/fume/gas/mist/vapours/spray.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.
安全信息
危险等级
3
包装组
III
危险类别
10-36/37/38
Flammable.Irritating to eyes, respiratory system and skin.
安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
TSCA
否
