应用
N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

备注
Air and moisture sensitive. Incompatible with strong oxidizing agents, water and acids.

基本信息

MDL
MFCD00008270

EINECS
233-892-7

分子式
C₈H₂₁NOSi₂

分子量
203.43

熔点
-24°

沸点
71-73°/35mm

闪点
42°(107°F)

密度
0.829

折射率
1.4170

灵敏度
Keep Cold. Moisture Sensitive.

形态
Liquid

溶解性
Miscible with many nonpolar and polar aprotic solvents.

Beilstein
1306669

GHS危害和防范说明

GHS符号

Hazard Statements
H226-H302-H314-H318
Flammable liquid and vapour.Harmful if swallowed.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P210-P260h-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Keep away from heat/sparks/open flames/hot surfaces. - No smoking.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
8

包装组
II

危险类别
10-14-22-34
Flammable.Reacts violently with water.Harmful if swallowed.Causes burns.

安全等级
26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

欧盟危险品标志

RTECS
AK3000000

TSCA
是