应用
It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Grade Specifications
Maximum level of impurities: Insoluble matter 0.1%, Residue after ignition 0.2%, Sensitivity to aluminum P.T.

备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

基本信息

MDL
MFCD00040925

EINECS
209-319-1

分子式
C₂₂H₂₃N₃O₉

分子量
473.44

熔点
220-225° dec.

灵敏度
Ambient temperatures.

形态
Powder

溶解性
Soluble in water(800g/L).

Merck
14,322

GHS危害和防范说明

GHS符号

Hazard Statements
H315-H319
Causes skin irritation.Causes serious eye irritation.

Precautionary Statements
P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313
Wear protective gloves and eye/face protection.Wash thoroughly after handling.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).If skin irritation occurs: Get medical advice/attention.If eye irritation persists: Get medical advice/attention.

安全信息

危险类别
36/38
Irritating to eyes and skin.

安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

RTECS
GU4800000

TSCA
是