应用
4-Acetylbutyric acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. It is also used to prepare PARP inhibitors for the treatment of cancer.
备注
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agents.
基本信息
MDL
MFCD00004412
EINECS
221-511-7
分子式
CH3CO(CH2)3CO2H
分子量
130.14
熔点
12-14°
沸点
274-275°
闪点
>110°(230°F)
密度
1.100
折射率
1.4451
灵敏度
Ambient temperatures.
溶解性
Slightly soluble in water, chloroform and methanol.
Beilstein
385840
GHS危害和防范说明
GHS符号
Hazard Statements
H315-H319
Causes skin irritation.Causes serious eye irritation.
Precautionary Statements
P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313
Wear protective gloves and eye/face protection.Wash thoroughly after handling.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).If skin irritation occurs: Get medical advice/attention.If eye irritation persists: Get medical advice/attention.
安全信息
危险类别
36/38
Irritating to eyes and skin.
安全等级
26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
TSCA
是