应用
An antibacterial and inhibitor of formylation. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.Trimethoprim is an antibiotic involved in the treatment of urinary tract infections, middle ear infections and traveler?’s diarrhea. It is associated with sulfamethoxazole and interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Furthermore, It is also used to treat and prevent Pneumocystis jiroveci pneumonia.
备注
Sensitive to light. Incompatible with strong oxidizing agents. Sore in a cool place.
基本信息
MDL
MFCD00036761
EINECS
212-006-2
分子式
C14H18N4O3
分子量
290.32
熔点
199-203°
灵敏度
Keep Cold.
形态
Powder
溶解性
Trimethoprim is soluble in water at 0.4 mg/ml. It is also soluble in DMSO at 50 mg/ml and chloroform at 18.2 mg/ml. Soluble in methanol, chloroform, dimethyl sulfoxide, N,N-dimethylacetamide, benzyl alcohol, and propylene glycol. Insoluble in water, diethyl ether and benzene.
Beilstein
625127
Merck
14,9709
安全信息
RTECS
UV8225000
TSCA
否
