应用
(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinson?’s disease, Alzheimer?’s disease, Huntington?’s disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.
备注
Stable under recommended storage conditions. Incompatible with oxidizing agents.
基本信息
MDL
MFCD00069299
分子式
C13H17N?HCl
分子量
223.74
灵敏度
Ambient temperatures.
形态
Crystalline Powder
溶解性
Soluble in water at 100mM
Merck
14,8428
GHS危害和防范说明
GHS符号
Hazard Statements
H315-H319
Causes skin irritation.Causes serious eye irritation.
Precautionary Statements
P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313
Wear protective gloves and eye/face protection.Wash thoroughly after handling.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Specific treatment (see label).If skin irritation occurs: Get medical advice/attention.If eye irritation persists: Get medical advice/attention.
安全信息
危险类别
36/38
Irritating to eyes and skin.
安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste
RTECS
DA0292500
TSCA
否
