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MAPKBP1抗体
交货期:1周


产品名称
Anti-MAPKBP1
Anti-mitogen-activated protein kinase binding protein 1 Antibody
产品介绍
靶标:

MAPKBP1


产品别名:

JNKBP-1; JNKBP1; NPHP20; MAPKBP1; mitogen-activated protein kinase binding protein 1; mitogen-activated protein kinase binding protein 1; mitogen-activated protein kinase-binding protein 1; JNK-binding protein 1;


背景信息:
This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.
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